| D1 | 07/05/1921 | Aston Villa | 2-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 30/04/1921 | Liverpool | 2-3 | Bolton Wanderers | Smith J 2, Jack D | | Unknown | Win |
| D1 | 23/04/1921 | Bolton Wanderers | 1-0 | Liverpool | Smith J | | 31,681 | Win |
| D1 | 16/04/1921 | Newcastle United | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 09/04/1921 | Bolton Wanderers | 3-1 | Newcastle United | Smith J 3 | | Unknown | Win |
| D1 | 04/04/1921 | Bolton Wanderers | 3-0 | Preston North End | Roberts F, Smith J, Walsh T | | Unknown | Win |
| D1 | 02/04/1921 | Bradford | 2-1 | Bolton Wanderers | Smith J | | Unknown | Loss |
| D1 | 28/03/1921 | Everton | 2-3 | Bolton Wanderers | Vizard, Smith J, Roberts F | | Unknown | Win |
| D1 | 26/03/1921 | Bolton Wanderers | 2-0 | Bradford | Jack D 2 | | Unknown | Win |
| D1 | 25/03/1921 | Bolton Wanderers | 4-2 | Everton | Jack D, Roberts F, Smith J 2 (1 pen) | | Unknown | Win |
| D1 | 19/03/1921 | Bolton Wanderers | 2-2 | Sheffield United | Smith J, Vizard | | Unknown | Draw |
| D1 | 12/03/1921 | Sheffield United | 2-2 | Bolton Wanderers | Roberts F 2 | | Unknown | Draw |
| D1 | 05/03/1921 | Bolton Wanderers | 1-1 | Burnley | Smith J | | 54,809 | Draw |
| D1 | 26/02/1921 | Burnley | 3-1 | Bolton Wanderers | Roberts F | | Unknown | Loss |
| D1 | 16/02/1921 | Bradford City | 2-2 | Bolton Wanderers | Roberts F, Smith J | | Unknown | Draw |
| D1 | 12/02/1921 | Preston North End | 1-2 | Bolton Wanderers | Roberts F 2 | | Unknown | Win |
| D1 | 05/02/1921 | Bolton Wanderers | 1-1 | Bradford City | Smith J | | 24,771 | Draw |
| D1 | 22/01/1921 | Bolton Wanderers | 1-1 | Oldham Athletic | Smith J | | Unknown | Draw |
| D1 | 15/01/1921 | Oldham Athletic | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| FAC1 | 08/01/1921 | Preston North End | 2-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 01/01/1921 | Bolton Wanderers | 1-0 | Tottenham Hotspur | Smith J (pen) | | 53,430 | Win |
| D1 | 27/12/1920 | Sunderland | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 25/12/1920 | Bolton Wanderers | 6-2 | Sunderland | Smith J 4, Seddon J, Roberts F | | 39,521 | Win |
| D1 | 18/12/1920 | Tottenham Hotspur | 5-2 | Bolton Wanderers | Smith J, Rowley | | Unknown | Loss |
| D1 | 11/12/1920 | Bolton Wanderers | 3-1 | Huddersfield Town | Smith J, Herbert, Roberts F | | Unknown | Win |
| D1 | 04/12/1920 | Huddersfield Town | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 27/11/1920 | Bolton Wanderers | 2-1 | Blackburn Rovers | Roberts F 2 | | Unknown | Win |
| D1 | 20/11/1920 | Blackburn Rovers | 2-2 | Bolton Wanderers | Smith J (pen), Roberts F | | Unknown | Draw |
| D1 | 13/11/1920 | Bolton Wanderers | 1-0 | Derby County | Seddon J | | Unknown | Win |
| D1 | 06/11/1920 | Derby County | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 30/10/1920 | Bolton Wanderers | 6-2 | Middlesbrough | Buchan, Smith J 3, Roberts F 2 | | Unknown | Win |
| D1 | 23/10/1920 | Middlesbrough | 4-1 | Bolton Wanderers | Smith J | | Unknown | Loss |
| D1 | 16/10/1920 | Bolton Wanderers | 1-1 | Arsenal | Smith J | | Unknown | Draw |
| D1 | 09/10/1920 | Arsenal | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 02/10/1920 | Manchester City | 3-1 | Bolton Wanderers | Smith J | | Unknown | Loss |
| D1 | 25/09/1920 | Bolton Wanderers | 3-0 | Manchester City | Smith J 2 (1 pen), Roberts F | | Unknown | Win |
| D1 | 18/09/1920 | West Bromwich Albion | 2-1 | Bolton Wanderers | Herbert | | Unknown | Loss |
| D1 | 15/09/1920 | Bolton Wanderers | 5-0 | Aston Villa | Roberts F 2, Buchan, Smith J 2 | | Unknown | Win |
| D1 | 11/09/1920 | Bolton Wanderers | 3-0 | West Bromwich Albion | Smith J 2, Roberts F | | Unknown | Win |
| D1 | 06/09/1920 | Bolton Wanderers | 3-1 | Chelsea | Roberts F 2, Smith J | | Unknown | Win |
| D1 | 04/09/1920 | Bolton Wanderers | 1-1 | Manchester United | Smith J | | 32,239 | Draw |
| D1 | 01/09/1920 | Chelsea | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 28/08/1920 | Manchester United | 2-3 | Bolton Wanderers | Roberts F 2, Guy | | Unknown | Win |