| D1 | 06/05/1922 | Bolton Wanderers | 4-2 | Middlesbrough | Jack D, Smith J, Rowley, Butler W | | Unknown | Win |
| D1 | 29/04/1922 | Middlesbrough | 4-2 | Bolton Wanderers | Jack D, Smith J | | Unknown | Loss |
| D1 | 22/04/1922 | Bolton Wanderers | 1-0 | Aston Villa | Roberts F | | Unknown | Win |
| D1 | 17/04/1922 | Bolton Wanderers | 1-1 | Sunderland | Smith J | | Unknown | Draw |
| D1 | 15/04/1922 | Aston Villa | 2-1 | Bolton Wanderers | Roberts F | | Unknown | Loss |
| D1 | 14/04/1922 | Sunderland | 6-2 | Bolton Wanderers | Roberts F, Smith J (pen) | | Unknown | Loss |
| D1 | 08/04/1922 | Bolton Wanderers | 1-0 | Manchester United | Jack D | | Unknown | Win |
| D1 | 01/04/1922 | Manchester United | 0-1 | Bolton Wanderers | Smith J | | Unknown | Win |
| D1 | 25/03/1922 | Bolton Wanderers | 1-3 | Liverpool | Smith J | | Unknown | Loss |
| D1 | 18/03/1922 | Liverpool | 0-2 | Bolton Wanderers | Jack D, Smith J (pen) | | Unknown | Win |
| D1 | 11/03/1922 | Newcastle United | 2-1 | Bolton Wanderers | Smith J | | Unknown | Loss |
| D1 | 04/03/1922 | Bolton Wanderers | 3-2 | Newcastle United | Roberts F, Bradley J (og), Smith J (pen) | | Unknown | Win |
| D1 | 25/02/1922 | Burnley | 2-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 18/02/1922 | Bolton Wanderers | 0-1 | Burnley | | | Unknown | Loss |
| D1 | 11/02/1922 | Sheffield United | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 04/02/1922 | Bolton Wanderers | 3-1 | Sheffield United | Roberts F 2, Jack D | | 7,408 | Win |
| FAC2 | 28/01/1922 | Bolton Wanderers | 1-3 | Manchester City | Roberts F | | 66,442 | Loss |
| D1 | 21/01/1922 | Bolton Wanderers | 0-2 | Chelsea | | | Unknown | Loss |
| D1 | 18/01/1922 | Chelsea | 0-3 | Bolton Wanderers | Buchan, Smith J 2 (1 pen) | | Unknown | Win |
| D1 | 14/01/1922 | Bolton Wanderers | 1-0 | Everton | Jack D | | Unknown | Win |
| FAC1 | 07/01/1922 | Bolton Wanderers | 1-0 | Bury | Vizard | | 42,831 | Win |
| D1 | 02/01/1922 | Bolton Wanderers | 5-1 | Oldham Athletic | Roberts F, Jack D 3, Smith J (pen) | | Unknown | Win |
| D1 | 31/12/1921 | Everton | 1-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 26/12/1921 | Oldham Athletic | 0-0 | Bolton Wanderers | | | Unknown | Draw |
| D1 | 24/12/1921 | Bolton Wanderers | 1-1 | Blackburn Rovers | Jack D | | Unknown | Draw |
| D1 | 17/12/1921 | Blackburn Rovers | 1-2 | Bolton Wanderers | Roberts F, Jack D | | Unknown | Win |
| D1 | 12/12/1921 | Arsenal | 1-1 | Bolton Wanderers | Jack D | | Unknown | Draw |
| D1 | 10/12/1921 | Bolton Wanderers | 5-0 | Manchester City | Roberts F 2, Jack D 2, Smith J | | Unknown | Win |
| D1 | 03/12/1921 | Manchester City | 2-3 | Bolton Wanderers | Jack D, Roberts F 2 | | Unknown | Win |
| D1 | 19/11/1921 | Bolton Wanderers | 1-0 | Arsenal | Jack D | | Unknown | Win |
| D1 | 12/11/1921 | Bolton Wanderers | 2-0 | West Bromwich Albion | Vizard, Roberts F | | Unknown | Win |
| D1 | 05/11/1921 | West Bromwich Albion | 0-1 | Bolton Wanderers | Jack D | | Unknown | Win |
| D1 | 29/10/1921 | Bolton Wanderers | 1-2 | Birmingham City | Roberts F | | Unknown | Loss |
| D1 | 22/10/1921 | Birmingham City | 1-1 | Bolton Wanderers | Roberts F | | Unknown | Draw |
| D1 | 15/10/1921 | Bolton Wanderers | 1-2 | Cardiff City | Roberts F | | Unknown | Loss |
| D1 | 08/10/1921 | Cardiff City | 1-2 | Bolton Wanderers | Buchan, Jack D | | Unknown | Win |
| D1 | 01/10/1921 | Huddersfield Town | 3-0 | Bolton Wanderers | | | Unknown | Loss |
| D1 | 24/09/1921 | Bolton Wanderers | 3-1 | Huddersfield Town | Smith J, Roberts F, Jack D | | Unknown | Win |
| D1 | 17/09/1921 | Bradford City | 4-3 | Bolton Wanderers | Jack D 2, Smith J | | Unknown | Loss |
| D1 | 10/09/1921 | Bolton Wanderers | 3-3 | Bradford City | Jack D 2, Roberts F | | Unknown | Draw |
| D1 | 05/09/1921 | Bolton Wanderers | 1-0 | Tottenham Hotspur | Vizard | | Unknown | Win |
| D1 | 03/09/1921 | Preston North End | 3-1 | Bolton Wanderers | Jack D | | Unknown | Loss |
| D1 | 29/08/1921 | Tottenham Hotspur | 1-2 | Bolton Wanderers | Smith J (pen), Vizard | | Unknown | Win |
| D1 | 27/08/1921 | Bolton Wanderers | 2-2 | Preston North End | Smith J 2 (1 pen) | | 39,993 | Draw |